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[前列腺癌的早期诊断。经直肠超声检查的假设作用]

[Early diagnosis of cancer of the prostate. Hypothetic role of transrectal echography].

作者信息

Perrin P, Mouriquand P, Monsallier M, Oukeira H, Maquet J H, Devonec M

机构信息

Service d'Urologie de l'Hôpital de l'Antiquaille, Lyon.

出版信息

Presse Med. 1989 Jul 1;18(26):1289-92.

PMID:2528133
Abstract

In order to clarify the value of transrectal ultrasonic examination of the prostate in the diagnosis of prostatic cancer at an early stage, 666 patients were screened in one year; 602 of them (TO) had a normal, firm or hypertrophic but non-nodular prostate at digital rectal palpation, 41 had a T1-T2 prostate and 23 a T3-T4 prostate. Among the 602 TO prostates, 162 showed a hypoechoic peripheral area which was biopsied, revealing an infiltrating carcinoma in 11 cases. The ability of transrectal ultrasound alone to detect TO cancer was estimated at 1.8 per cent (11/602). The positive predictive value of a hypoechoic image of the prostate was estimated at 7 per cent (11/162), which is much lower than the figures reported in the literature. Transrectal ultrasound can be considered an acceptable method for detecting TO tumours of the prostate with a yield comparable to that of digital rectal palpation in the T1-T2 tumours. The low performance (1.8 per cent) of transrectal ultrasound in detecting cancer at an early stage rules out any mass screening programme of the male population over 50 years of age. However, 45 per cent of localized tumours in this series were detected by transrectal ultrasound.

摘要

为了阐明经直肠超声检查前列腺在早期诊断前列腺癌中的价值,一年内对666例患者进行了筛查;其中602例(TO)经直肠指诊前列腺正常、质地硬或肥大但无结节,41例为T1-T2期前列腺,23例为T3-T4期前列腺。在602例TO期前列腺中,162例显示外周低回声区,对其进行活检,11例发现浸润性癌。单纯经直肠超声检测TO期癌的能力估计为1.8%(11/602)。前列腺低回声图像的阳性预测值估计为7%(11/162),远低于文献报道的数据。经直肠超声可被认为是检测前列腺TO期肿瘤的一种可接受方法,其检出率与T1-T2期肿瘤的直肠指诊相当。经直肠超声在早期检测癌症方面的低性能(1.8%)排除了对50岁以上男性人群进行任何大规模筛查计划的可能性。然而,该系列中45%的局限性肿瘤是通过经直肠超声检测到的。

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