Redwan Elrashdy M, Uversky Vladimir N, El-Fakharany Esmail M, Al-Mehdar Hussein
Biology Department, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah 21589, Saudi Arabia; Therapeutic and Protective Proteins Laboratory, Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City for Scientific Research and Technological Applications, New Borg EL-Arab 21394, Alexandria, Egypt.
Biology Department, Faculty of Science, King Abdulaziz University, PO Box 80203, Jeddah 21589, Saudi Arabia; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia.
C R Biol. 2014 Oct;337(10):581-95. doi: 10.1016/j.crvi.2014.08.003. Epub 2014 Sep 22.
Lactoferrin (LF) is an 80-kDa globular glycoprotein with high affinity for metal ions, particularly for iron. This protein possesses many biological functions, including the binding and release of iron and serves as one of the important components of the innate immune system, where it acts as a potent inhibitor of several pathogens. LF has efficacious antibacterial and antiviral activities against a wide range of Gram-positive and Gram-negative bacteria and against both naked and enveloped DNA and RNA viruses. In its antiviral pursuit, LF acts predominantly at the acute phase of the viral infection or even at the intracellular stage, as in hepatitis C virus infection. LF inhibits the entry of viral particles into host cells, either by direct attachment to the viral particles or by blocking their cellular receptors. This wide range of activities may be attributed to the capacity of LF to bind iron and its ability to interfere with the cellular receptors of both hosts and pathogenic microbes.
乳铁蛋白（LF）是一种80千道尔顿的球状糖蛋白，对金属离子，尤其是铁具有高亲和力。这种蛋白质具有许多生物学功能，包括铁的结合与释放，并且是先天免疫系统的重要组成部分之一，在其中作为几种病原体的有效抑制剂。乳铁蛋白对多种革兰氏阳性和革兰氏阴性细菌以及裸露和包膜的DNA和RNA病毒均具有有效的抗菌和抗病毒活性。在其抗病毒过程中，乳铁蛋白主要在病毒感染的急性期甚至在细胞内阶段发挥作用，如在丙型肝炎病毒感染中。乳铁蛋白通过直接附着于病毒颗粒或阻断其细胞受体来抑制病毒颗粒进入宿主细胞。这种广泛的活性可能归因于乳铁蛋白结合铁的能力及其干扰宿主和致病微生物细胞受体的能力。
