Diaz Jennifer, Farzan Sherry
North Shore-Long Island Jewish Health System, Division of Allergy and Immunology, Hofstra School of Medicine, 865 Northern Boulevard, Suite 101, Great Neck, NY 11021, USA.
North Shore-Long Island Jewish Health System, Division of Allergy and Immunology, Hofstra School of Medicine, 865 Northern Boulevard, Suite 101, Great Neck, NY 11021, USA.
Immunol Allergy Clin North Am. 2014 Nov;34(4):739-51. doi: 10.1016/j.iac.2014.07.008.
The concomitant increase in obesity and asthma in recent years has led to the classification of two obese-asthma phenotypes, characterized by the age of asthma onset and atopy. Asthma tends to be more severe, harder to control, and more resistant to standard medications among members of these two groups. Because of the limited effectiveness of inhaled corticosteroids, dietary changes and weight loss measures must be considered in the management of these patients. Furthermore, comorbidities such as depression and obstructive sleep apnea must be addressed to provide optimal care for this group of difficult-to-control asthmatics.
近年来肥胖症和哮喘的并发率上升，导致了两种肥胖型哮喘表型的分类，这两种表型以哮喘发病年龄和特应性为特征。在这两组人群中，哮喘往往更严重、更难控制，且对标准药物的耐药性更强。由于吸入性糖皮质激素效果有限，在治疗这些患者时必须考虑饮食调整和减肥措施。此外，还必须解决诸如抑郁症和阻塞性睡眠呼吸暂停等合并症，以便为这组难以控制的哮喘患者提供最佳治疗。
