Purrmann J, Bertrams J, Knapp M, Cleveland S, Gemsa R, Hengels K J, Strohmeyer G
Department of Gastroenterology, University of Düsseldorf, F.R.G.
Z Gastroenterol. 1989 Jul;27(7):366-9.
Inflammatory bowel diseases (IBD) as Crohn's disease (CD) and ulcerative colitis (UC) are believed to have a genetic basis. Additional factors are supposed to promote the development of IBD. However, apart from a few reports of HLA associations which await confirmation by other groups strong associations to (a) particular genetic marker(s) are still lacking. We here report on previously unobserved associations of CD to MNSS and UC to the immunoglobulin heavy chain allotype Gm 1,-2,10. We suggest that these factors play a role in a wider spectrum of genetic markers for the development of IBD.
炎症性肠病（IBD），如克罗恩病（CD）和溃疡性结肠炎（UC），被认为具有遗传基础。其他因素被认为会促进IBD的发展。然而，除了少数关于HLA关联的报告有待其他研究小组证实外，与特定遗传标记的强关联仍然缺乏。我们在此报告CD与MNSS以及UC与免疫球蛋白重链同种异型Gm 1，-2，10之间以前未观察到的关联。我们认为这些因素在IBD发展的更广泛遗传标记谱中发挥作用。
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