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遗传标记与炎症性肠病:免疫球蛋白同种异型(GM、KM)及蛋白酶抑制剂

Genetic markers and inflammatory bowel disease: immunoglobulin allotypes (GM, KM) and protease inhibitor.

作者信息

Field L L, Boyd N, Bowen T J, Kelly J K, Sutherland L R

机构信息

Department of Pediatrics, University of Calgary, Alberta, Canada.

出版信息

Am J Gastroenterol. 1989 Jul;84(7):753-5.

PMID:2741885
Abstract

We have studied immunoglobulin allotypes (GM and KM) in 101 patients with Crohn's disease, 51 patients with ulcerative colitis, and 99 healthy local blood donor controls. In addition, protease inhibitor (PI) types were examined in a random subset of patients and in all controls. No significant differences were found between Crohn's disease patients and controls, or between ulcerative colitis patients and controls, in the frequencies of GM phenotypes, GM haplotypes, KM phenotypes, or PI phenotypes.

摘要

我们研究了101例克罗恩病患者、51例溃疡性结肠炎患者以及99名当地健康献血者对照的免疫球蛋白同种异型(GM和KM)。此外,还在部分随机选取的患者及所有对照中检测了蛋白酶抑制剂(PI)类型。在GM表型、GM单倍型、KM表型或PI表型的频率方面,克罗恩病患者与对照之间、溃疡性结肠炎患者与对照之间均未发现显著差异。

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Gut. 1992 Oct;33(10):1358-64. doi: 10.1136/gut.33.10.1358.