Thorell Sofia E, Parry-Jones Adrian R, Punter Martin, Hurford Robert, Thachil Jecko
School of Medicine, University of Manchester, Oxford Road, Manchester, UK.
Department of Neurology, Salford Royal Hospital, Stott Lane, Salford, UK.
Blood Rev. 2015 Jan;29(1):45-50. doi: 10.1016/j.blre.2014.09.006. Epub 2014 Sep 20.
Cerebral venous thrombosis (CVT) is a condition that can affect all age groups and can often be difficult to diagnose and treat. The difficulties in diagnosis are mainly due to the non-specific presenting features of CVT, which can range from isolated headache and visual or auditory problems, to serious symptoms such as hemiparesis and coma. Therefore, it can present to various specialists including general physicians, obstetricians and neurologists. In recent years, more widespread use of cerebral imaging has led to the diagnosis being made more often. Since thrombosis is the key component, haematologists are consulted in the management of these patients including for identification of a causative factor for CVT. In this regard, the pivotal International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) has shed more light on its epidemiology and management options. This review aims to provide guidance to haematologists when faced with a patient with CVT, based on the currently available evidence.
脑静脉血栓形成(CVT)是一种可影响所有年龄组的疾病,通常难以诊断和治疗。诊断困难主要是由于CVT的临床表现不具特异性,其症状范围从单纯头痛、视觉或听觉问题到偏瘫和昏迷等严重症状。因此,CVT患者可能会就诊于包括普通内科医生、产科医生和神经科医生在内的各类专科医生。近年来,脑成像技术的更广泛应用使得CVT的诊断更为常见。由于血栓形成是关键因素,血液科医生会参与这些患者的管理,包括确定CVT的病因。在这方面,具有关键意义的国际脑静脉和硬脑膜窦血栓形成研究(ISCVT)为其流行病学和管理方案提供了更多信息。本综述旨在根据现有证据,为血液科医生在面对CVT患者时提供指导。