Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Allergy. 2014 Dec;69(12):1571-81. doi: 10.1111/all.12529.
Skin diseases with an allergic background such as atopic dermatitis, allergic contact dermatitis, and urticaria are very common. Moreover, diseases arising from a dysfunction of immune cells and/or their products often manifest with skin symptoms. This review aims to summarize recently published articles in order to highlight novel research findings, clinical trial results, and current guidelines on disease management. In recent years, an immense progress has been made in understanding the link between skin barrier dysfunction and allergic sensitization initiating the atopic march. In consequence, new strategies for treatment and prevention have been developed. Novel pathogenic insights, for example, into urticaria, angioedema, mastocytosis, led to the development of new therapeutic approaches and their implementation in daily patient care. By understanding distinct pathomechanisms, for example, the role of IL-1, novel entities such as autoinflammatory diseases have been described. Considerable effort has been made to improve and harmonize patient management as documented in several guidelines and position papers.
具有过敏背景的皮肤疾病，如特应性皮炎、过敏性接触性皮炎和荨麻疹，非常常见。此外，由免疫细胞和/或其产物功能障碍引起的疾病通常表现为皮肤症状。本综述旨在总结最近发表的文章，以突出有关疾病管理的新研究发现、临床试验结果和当前指南。近年来，人们在理解皮肤屏障功能障碍与引发特应性进程的过敏致敏之间的联系方面取得了巨大进展。因此，已经开发出治疗和预防的新策略。例如，对荨麻疹、血管性水肿、肥大细胞增多症的新发病机制的深入了解，导致了新的治疗方法的发展，并将其应用于日常患者护理。通过了解不同的发病机制，例如白细胞介素 1 的作用，已经描述了自身炎症性疾病等新实体。正如几项指南和立场文件所记录的那样，人们已经做出了相当大的努力来改善和协调患者管理。
