[1例丙型慢性肝炎合并胰腺分裂症患者在特拉匹韦/聚乙二醇干扰素/利巴韦林联合治疗期间发生急性胰腺炎]

[A case of chronic hepatitis C with pancreas divisum and acute pancreatitis during combination treatment with telaprevir/peginterferon/ribavirin].

作者信息

Morio Reona, Imamura Michio, Fukuhara Takayuki, Kan Hiromi, Fujino Hatsue, Kawaoka Tomokazu, Hiramatsu Akira, Aikata Hiroshi, Sasaki Tamito, Chayama Kazuaki

机构信息

Department of Gastroenterology and Metabolism, Hiroshima University Hospital.

出版信息

Nihon Shokakibyo Gakkai Zasshi. 2014 Oct;111(10):1997-2003.

PMID:25283229

Abstract

A 47-year-old man developed acute pancreatitis during combination treatment with telaprevir/peginterferon/ribavirin for chronic hepatitis C. Cessation of telaprevir, fasting, and gabexate mesilate improved the pancreatitis. Although peginterferon and ribavirin treatment was continued, there was no recurrence of the pancreatitis. Endoscopic retrograde cholangiopancreatography incidentally showed a pancreas divisum. We definitively diagnosed drug-induced acute pancreatitis due to telaprevir.

摘要

一名47岁男性在接受特拉匹韦/聚乙二醇干扰素/利巴韦林联合治疗慢性丙型肝炎期间发生了急性胰腺炎。停用特拉匹韦、禁食和使用甲磺酸加贝酯后，胰腺炎病情有所改善。尽管继续使用聚乙二醇干扰素和利巴韦林治疗，但胰腺炎未复发。内镜逆行胰胆管造影偶然发现胰腺分裂症。我们明确诊断为特拉匹韦所致的药物性急性胰腺炎。