Matsunaga A, Miller B C, Cottam G L
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235.
Biochim Biophys Acta. 1989 Sep 15;992(3):265-71. doi: 10.1016/0304-4165(89)90084-6.
The effect of dietary dehydroisoandrosterone (DHA) on several immunological abnormalities associated with the development of systemic lupus erythematosus in New Zealand Black/New Zealand White F1 (NZB/W) female mice was examined. Despite the extraordinary benefits in prolonged survival and decreased synthesis of antibodies to double-stranded DNA obtained by adding DHA (0.4% w/v) to the diet fed to these mice (Lucas et al. (1985) J. Clin. Invest. 75, 2091-2093), remarkably small changes in the chemistry and function of the immune system were detected. DHA prevented the increases in spleen mass and in peritoneal cell number which occur with age in NZB/W female mice, but did not prevent the development of hypergammaglobulinemia. DHA did not affect peritoneal macrophage functions as measured by the phagocytosis of opsonized and non-opsonized sheep erythrocytes, or the zymosan-stimulated release of PGE2, 6-ketoPGF1 alpha, TXB2 and LTC4. In spleen, DHA delayed the loss of T-cell mitogenic responses until 5.5 months of age, but did not alter the spleen lymphocyte population.
研究了饮食中脱氢表雄酮（DHA）对新西兰黑/新西兰白F1（NZB/W）雌性小鼠系统性红斑狼疮发展相关的几种免疫异常的影响。尽管在这些小鼠的饮食中添加DHA（0.4% w/v）可显著延长生存期并减少双链DNA抗体的合成（Lucas等人，（1985年）《临床研究杂志》75卷，2091 - 2093页），但检测到免疫系统的化学和功能变化非常小。DHA可防止NZB/W雌性小鼠随着年龄增长出现的脾脏肿大和腹腔细胞数量增加，但不能防止高球蛋白血症的发展。DHA不影响通过调理和未调理的绵羊红细胞吞噬作用以及酵母聚糖刺激的PGE2、6 - 酮PGF1α、TXB2和LTC4释放所测量的腹腔巨噬细胞功能。在脾脏中，DHA将T细胞促有丝分裂反应的丧失延迟至5.5月龄，但未改变脾脏淋巴细胞群体。
