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在喂食脱氢表雄酮的新西兰黑/新西兰白F1小鼠中预防自身抗体形成并延长生存期。

Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone.

作者信息

Lucas J A, Ahmed S A, Casey M L, MacDonald P C

出版信息

J Clin Invest. 1985 Jun;75(6):2091-3. doi: 10.1172/JCI111929.

DOI:10.1172/JCI111929
PMID:3159756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC425571/
Abstract

Dehydroisoandrosterone, administered orally to New Zealand Black/New Zealand White F1 hybrid mice, prevented the formation of antibodies to double-stranded DNA and prolonged survival in this murine model of lupus erythematosus.

摘要

对新西兰黑/新西兰白F1杂交小鼠口服脱氢表雄酮，可预防双链DNA抗体的形成，并延长这种红斑狼疮小鼠模型的生存期。

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Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone.在喂食脱氢表雄酮的新西兰黑/新西兰白F1小鼠中预防自身抗体形成并延长生存期。
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本文引用的文献

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STUDIES ON THE SECRETION AND INTERCONVERSION OF THE ANDROGENS.雄激素的分泌与相互转化研究
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2
THE NATURAL HISTORY OF AUTOIMMUNE DISEASE IN NZB MICE. A COMPARISON WITH THE PATTERN OF HUMAN AUTOIMMUNE MANIFESTATIONS.新西兰黑鼠自身免疫性疾病的自然史。与人类自身免疫表现模式的比较。
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Inhibition of 7,12-dimethylbenz[a]anthracene- and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone.长期使用脱氢表雄酮对A/J小鼠中7,12-二甲基苯并[a]蒽和乌拉坦诱导的肺肿瘤形成的抑制作用。
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Prevention of glomerulonephritis and prolonged survival in New Zealand Black/New Zealand White F1 hybrid mice fed an essential fatty acid-deficient diet.在喂食缺乏必需脂肪酸饮食的新西兰黑/新西兰白F1杂交小鼠中预防肾小球肾炎并延长生存期。
J Clin Invest. 1981 Feb;67(2):476-85. doi: 10.1172/JCI110056.
5
Reduction of circulating immune complexes by calorie restriction in (NZB x NZW) F1 mice.热量限制对（新西兰黑鼠×新西兰白鼠）F1代小鼠循环免疫复合物的影响。
Clin Immunol Immunopathol. 1980 Mar;15(3):293-300. doi: 10.1016/0090-1229(80)90041-0.
6
Therapeutic effects of dehydroepiandrosterone metabolites in diabetes mutant mice (C57BL/KsJ-db/db).脱氢表雄酮代谢产物对糖尿病突变小鼠（C57BL/KsJ-db/db）的治疗作用。
Endocrinology. 1984 Jul;115(1):239-43. doi: 10.1210/endo-115-1-239.
7
Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice.基因背景对脱氢表雄酮（DHEA）在糖尿病肥胖突变体和老年正常小鼠中治疗效果的影响。
Diabetes. 1984 Jan;33(1):26-32. doi: 10.2337/diab.33.1.26.
8
Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.脱氢表雄酮（DHEA）对糖尿病小鼠的治疗作用。
Diabetes. 1982 Sep;31(9):830-3. doi: 10.2337/diab.31.9.830.
9
Dehydroepiandrosterone: an anti-obesity and anti-carcinogenic agent.脱氢表雄酮：一种抗肥胖和抗癌剂。
Nutr Cancer. 1981;3(1):46-53. doi: 10.1080/01635588109513700.
10
Dietary influence on breeding behavior, hemolytic anemia, and longevity in NZB mice.饮食对新西兰黑鼠繁殖行为、溶血性贫血及寿命的影响。
Proc Soc Exp Biol Med. 1972 Apr;139(4):1189-96. doi: 10.3181/00379727-139-36327.