双膦酸盐治疗的骨质疏松症患者中Vγ9Vδ2 T淋巴细胞的激活
Vγ9Vδ2 T lymphocytes activation in osteoporotic patients treated with bisphosphonates.
作者信息
Sprini Delia, Di Stefano Laura, Rini Giovam Battista, Cianferotti Luisella, Napoli Nicola
机构信息
Department of Internal Medicine, University of Palermo, Italy.
Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
出版信息
Clin Cases Miner Bone Metab. 2014 May;11(2):126-8.
Treatment with bisphosphonates induces differentiation and activation of Vγ9Vδ2 T lymphocytes obtained from peripheral blood showing also an antitumoral effect in both in vitro and in vivo models. Aim of the present study was to determine in vivo the effect of BPs treatment in patients affected with osteoporosis on Vγ9Vδ2 T lymphocytes. We have studied Vγ9Vδ2 T lymphocytes expansion and differentiation from PBMC obtained from osteoporotic patients treated with one of the following bisphosphonates zoledronate, alendronate, neridronate or risedronate. We have found that zoledronic acid, followed by alendronate was the most effective on reducing CM population (100%) and increasing TEM and TEMRA γδ population. Our results indicate that in vivo treatment with BPs induces Vγ9Vδ2 cells to mature toward the effector phenotype, which may induce more antiresorptive responses.
双膦酸盐治疗可诱导从外周血获得的Vγ9Vδ2 T淋巴细胞分化和激活，在体外和体内模型中均显示出抗肿瘤作用。本研究的目的是在体内确定双膦酸盐治疗对骨质疏松症患者Vγ9Vδ2 T淋巴细胞的影响。我们研究了从接受以下双膦酸盐之一（唑来膦酸、阿仑膦酸、奈立膦酸或利塞膦酸）治疗的骨质疏松症患者的外周血单核细胞中Vγ9Vδ2 T淋巴细胞的扩增和分化。我们发现，唑来膦酸其次是阿仑膦酸在减少中央记忆（CM）群体（100%）和增加效应记忆T细胞（TEM）和末端效应记忆T细胞（TEMRA）γδ群体方面最有效。我们的结果表明，双膦酸盐的体内治疗可诱导Vγ9Vδ2细胞向效应表型成熟，这可能会诱导更多的抗吸收反应。
Zotero 插件