Atrio Jessica, Stek Alice, Vora Hita, Sanchez-Keeland Lorraine, Zannat Ferdous, Natavio Melissa
* Department of Obstetrics and Gynecology , Los Angeles, California , USA.
Eur J Contracept Reprod Health Care. 2015 Apr;20(2):149-53. doi: 10.3109/13625187.2014.957826. Epub 2014 Oct 6.
To compare cervical mucus score (CMS) with and without protease inhibitors (PI) before and after taking norethindrone (NET).
This two-arm, researcher blinded, non-randomised, prospective study was conducted to evaluate cervical mucus quality in HIV-positive women taking progestin only pills. The study group was taking a PI, and compared to women taking ARV regimens that have demonstrated no significant interaction with NET in prior pharmacokinetic trials with combined oral contraceptives. The women had a cervical mucus score prior to NET administration. Mucus Scoring was repeated after 21 days of steady state exposure to oral NET 0.35 milligrams. Cervical mucus quality was quantified according to the World Health Organisation criteria, which include: volume, consistency, cellularity, spinnbarkeit, and ferning.
Sixteen women took PI and 17 were controls. Baseline CMS were similar (p ≥ 0.1). After 21 days CMS were similar among the two groups (p = 1).
HIV-positive women taking PI demonstrated thickened cervical mucus with oral norethindrone 0.35 mg and are similar to HIV-positive women taking no PI therapy. This may suggest no difference in contraceptive efficacy of progestin only pills in HIV-positive women taking PI.
比较服用炔诺酮（NET）前后使用和不使用蛋白酶抑制剂（PI）时的宫颈黏液评分（CMS）。
本双臂、研究者设盲、非随机前瞻性研究旨在评估仅服用孕激素避孕药的HIV阳性女性的宫颈黏液质量。研究组服用PI，并与在先前联合口服避孕药的药代动力学试验中已证明与NET无显著相互作用的接受抗逆转录病毒治疗方案的女性进行比较。这些女性在服用NET前有宫颈黏液评分。在稳定暴露于0.35毫克口服NET 21天后重复进行黏液评分。根据世界卫生组织标准对宫颈黏液质量进行量化，该标准包括：量、黏稠度、细胞成分、拉丝度和羊齿状结晶。
16名女性服用PI，17名作为对照。基线CMS相似（p≥0.1）。21天后两组间CMS相似（p = 1）。
服用PI的HIV阳性女性在口服0.35毫克炔诺酮时宫颈黏液变厚，且与未接受PI治疗的HIV阳性女性相似。这可能表明仅服用孕激素避孕药对服用PI的HIV阳性女性的避孕效果无差异。
