Arrieta-Bolaños Esteban, Madrigal J Alejandro, Marsh Steven G E, Shaw Bronwen E, Salazar-Sánchez Lizbeth
Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London, UK; Cancer Institute, University College London, Royal Free Campus, London, UK; Centro de Investigaciones en Hematología y Trastornos Afines (CIHATA), Universidad de Costa Rica, San José, Costa Rica.
Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London, UK; Cancer Institute, University College London, Royal Free Campus, London, UK.
Hum Immunol. 2014 Nov;75(11):1092-6. doi: 10.1016/j.humimm.2014.09.011. Epub 2014 Oct 5.
HLA-B(∗)57:01 is a well-known and cost-effective pharmacogenetic marker for abacavir hypersensitivity. As with other HLA alleles, there is widespread variation in its frequency across populations. The Costa Rica Central Valley Population (CCVP) is the major population in this country. The frequency of HLA-B(∗)57:01 in this population has not been described yet. Thus, our aim was to determine the frequency of this allele in the CCVP. 200 unrelated healthy volunteer donors born in the CCVP were typed. HLA-B(∗)57-positive samples identified by HLA intermediate resolution typing methods were further typed by SBT to high resolution. An HLA-B(∗)57:01 carrier frequency of 5.00% was determined in this sample. This frequency is relatively high in comparison to reports from other populations in Latin America. These results suggest that there is a considerable frequency of HLA-B(∗)57:01 in the CCVP and that pharmacogenetic testing for HIV+ patients who are going to receive abacavir-based treatment should be considered in this country.
HLA - B(∗)57:01是一种广为人知且具有成本效益的阿巴卡韦超敏反应药物遗传学标志物。与其他HLA等位基因一样，其在不同人群中的频率存在广泛差异。哥斯达黎加中央山谷人群（CCVP）是该国的主要人群。该人群中HLA - B(∗)57:01的频率尚未见报道。因此，我们的目的是确定CCVP中该等位基因的频率。对200名出生于CCVP的无亲缘关系健康志愿者供体进行了分型。通过HLA中等分辨率分型方法鉴定出的HLA - B(∗)57阳性样本进一步通过SBT进行高分辨率分型。在该样本中确定HLA - B(∗)57:01的携带频率为5.00%。与拉丁美洲其他人群的报告相比，该频率相对较高。这些结果表明，CCVP中HLA - B(∗)57:01的频率相当可观，并且在该国应考虑对即将接受基于阿巴卡韦治疗的HIV阳性患者进行药物遗传学检测。
