Moragas M, Belloso W H, Baquedano M S, Gutierrez M I, Bissio E, Larriba J M, Fay F, Aulicino P, Gurevich J M, Yaunguzian M F, Maldonado A C, Falistocco C, Sen L, Mangano A
Laboratorio de Biología Celular y Retrovirus-CONICET, Hospital de Pediatría 'Prof. Dr Juan P. Garrahan', Buenos Aires, Argentina.
Instituto de Ciencias Básicas y Medicina Experimental, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Tissue Antigens. 2015 Jul;86(1):28-31. doi: 10.1111/tan.12575. Epub 2015 Apr 29.
Hypersensitivity reaction to abacavir (ABC hypersensitivity syndrome, AHS) is strongly associated with the presence of the HLA-B57:01 allele. This study was designed to estimate the prevalence of HLA-B57:01 allele in Argentinean HIV-1 infected patients. We analyzed the presence of HLA-B57:01 allele in 1646 HIV-1 infected patients from different regions of Argentina. This allele was detected in 81 patients; most of them corresponded to patients living in the central region of the country. The prevalence of HLA-B57:01 was 4.9%, similar to other Caucasian populations and higher than other data reported for South American populations. This strongly supports screening for the presence of HLA-B*57:01 in abacavir treatment of HIV-1 in our country.
对阿巴卡韦的超敏反应（阿巴卡韦超敏综合征，AHS）与HLA - B57:01等位基因的存在密切相关。本研究旨在评估阿根廷HIV - 1感染患者中HLA - B57:01等位基因的流行率。我们分析了来自阿根廷不同地区的1646例HIV - 1感染患者中HLA - B57:01等位基因的存在情况。在81例患者中检测到该等位基因；其中大多数是居住在该国中部地区的患者。HLA - B57:01的流行率为4.9%，与其他白种人群相似，高于报道的南美人群的其他数据。这有力地支持了在我国对HIV - 1患者进行阿巴卡韦治疗时筛查HLA - B*57:01的存在情况。
