取代的1,2-二氢吡啶的一般合成方法。
General synthesis of substituted 1,2-dihydropyridines.
作者信息
Tejedor David, Cotos Leandro, Méndez-Abt Gabriela, García-Tellado Fernando
机构信息
Departamento de Química Biológica y Biotecnología, Instituto de Productos Naturales y Agrobiología, CSIC , Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
出版信息
J Org Chem. 2014 Nov 7;79(21):10655-61. doi: 10.1021/jo501991s. Epub 2014 Oct 14.
A general and practical metal-free protocol for the synthesis of 1,2-dihydropyridines with wide structural/functional diversity at the ring and featuring mono, double, or spiro substitution at the sp(3) position is described. The protocol entails a microwave-assisted domino reaction of a propargyl vinyl ether (secondary or tertiary) and a primary amine (aliphatic or aromatic) in toluene or methanol.
描述了一种通用且实用的无金属方法，用于合成在环上具有广泛结构/功能多样性且在sp(3)位置具有单取代、双取代或螺取代的1,2-二氢吡啶。该方法包括在甲苯或甲醇中，炔丙基乙烯基醚（仲或叔）与伯胺（脂肪族或芳香族）的微波辅助多米诺反应。
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