Pasunooti Kalyan Kumar, Nixon Jensen Chantel, Chai Hua, Leow Min Li, Zhang Da-Wei, Liu Xue-Wei
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical, Sciences, Nanyang Technological University, Singapore 637371, Singapore.
J Comb Chem. 2010 Jul 12;12(4):577-81. doi: 10.1021/cc100060s.
A fast and highly efficient copper-catalyzed multicomponent synthesis of 1,4-dihydropyridines under microwave irradiation is described. The protocol utilizes mild reaction conditions with low catalytic loading, leading to high yields. This methodology provides us with biologically active 1,4-dihydropyridine library for medicinal chemistry applications.
本文描述了一种在微波辐射下快速高效的铜催化多组分合成1,4-二氢吡啶的方法。该方案采用温和的反应条件和低催化负载量，从而实现高产率。这种方法为药物化学应用提供了具有生物活性的1,4-二氢吡啶库。
