Rozeske R R, Valerio S, Chaudun F, Herry C
INSERM U862, Neurocenter Magendie, Bordeaux, France.
Genes Brain Behav. 2015 Jan;14(1):22-36. doi: 10.1111/gbb.12181. Epub 2014 Oct 27.
Over the past years, numerous studies have provided a clear understanding of the neuronal circuits and mechanisms involved in the formation, expression and extinction phases of conditioned cued fear memories. Yet, despite a strong clinical interest, a detailed understanding of these memory phases for contextual fear memories is still missing. Besides the well-known role of the hippocampus in encoding contextual fear behavior, growing evidence indicates that specific regions of the medial prefrontal cortex differentially regulate contextual fear acquisition and storage in both animals and humans that ultimately leads to expression of contextual fear memories. In this review, we provide a detailed description of the recent literature on the role of distinct prefrontal subregions in contextual fear behavior and provide a working model of the neuronal circuits involved in the acquisition, expression and generalization of contextual fear memories.
在过去几年中，众多研究已使我们对条件性线索恐惧记忆的形成、表达和消退阶段所涉及的神经回路及机制有了清晰的认识。然而，尽管临床上对此兴趣浓厚，但对于情境恐惧记忆的这些记忆阶段仍缺乏详细了解。除了海马体在编码情境恐惧行为中众所周知的作用外，越来越多的证据表明，内侧前额叶皮质的特定区域在动物和人类中对情境恐惧的获取和存储有不同的调节作用，最终导致情境恐惧记忆的表达。在这篇综述中，我们详细描述了近期关于不同前额叶亚区域在情境恐惧行为中作用的文献，并提供了一个涉及情境恐惧记忆获取、表达和泛化的神经回路工作模型。
