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微创全保守髋关节表面置换术后两年血清金属离子水平:一项前瞻性研究的初步结果

Two-year serum metal ion levels in minimally invasive total conservative hip resurfacing: preliminary results of a prospective study.

作者信息

Tai Stephen M, Millard Natascha, Munir Selin, Jenabzadeh Amir R, Walter Leonard R, Walter William L

机构信息

Mater Clinic, Specialist Orthopaedic Group, Sydney, New South Wales, Australia.

出版信息

ANZ J Surg. 2015 Mar;85(3):164-8. doi: 10.1111/ans.12868. Epub 2014 Oct 7.

Abstract

BACKGROUND

Metal-on-metal (MoM) hip resurfacings have been associated with the potential development of metallic debris and its associated pathology. Serum cobalt and chromium levels are a reliable surrogate marker of wear rates in MoM bearings. The aim of the study was to examine the trend in serum metal ion levels in the initial 2-year post-operative period following implantation of the minimally invasive total conservative hip MoM hip resurfacing and to determine whether head size, acetabular component orientation, clinical outcome scores or post-operative range of movement would affect these levels.

METHODS

In this prospective cohort study, serum cobalt and chromium ion levels were measured pre- and post-operatively in 25 patients who underwent minimally invasive total conservative hip MoM hip resurfacing. The results were correlated with acetabular component orientation, head size, outcome scores and post-operative range of movement.

RESULTS

The mean serum cobalt and chromium levels at 2 years were 1.2 ppb (0.4-4.4 ppb) and 2.1 ppb (0.7-5.7 ppb). The mean cup inclination was 43° (30°-60°) and anteversion was 18° (1°-47°). There was no clear relationship between serum ions and acetabular component orientation, outcome scores or range of movement. Patients with a head size ≤52 mm had significantly higher metal ion levels (cobalt P = 0.02, chromium P = 0.045).

CONCLUSION

Our preliminary results show all patients had cobalt and chromium levels below those indicating a high-risk implant, suggesting successful early outcome from minimally invasive total conservative hip resurfacing surgery.

摘要

背景

金属对金属(MoM)髋关节表面置换术与金属碎屑的潜在形成及其相关病理状况有关。血清钴和铬水平是MoM关节假体磨损率的可靠替代指标。本研究的目的是检测微创全保守型MoM髋关节表面置换术后最初2年血清金属离子水平的变化趋势,并确定股骨头尺寸、髋臼假体方位、临床结局评分或术后活动范围是否会影响这些水平。

方法

在这项前瞻性队列研究中,对25例行微创全保守型MoM髋关节表面置换术的患者术前和术后测量血清钴和铬离子水平。将结果与髋臼假体方位、股骨头尺寸、结局评分和术后活动范围进行相关性分析。

结果

2年时血清钴和铬的平均水平分别为1.2 ppb(0.4 - 4.4 ppb)和2.1 ppb(0.7 - 5.7 ppb)。髋臼杯平均倾斜角为43°(30° - 60°),前倾角为18°(1° - 47°)。血清离子水平与髋臼假体方位、结局评分或活动范围之间无明显关系。股骨头尺寸≤52 mm的患者金属离子水平显著更高(钴P = 0.02,铬P = 0.045)。

结论

我们的初步结果显示,所有患者的钴和铬水平均低于提示植入物高风险的水平,表明微创全保守型髋关节表面置换手术早期预后良好。

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