Declercq Dimitri, Van Biervliet Stephanie, Robberecht Eddy
Cystic Fibrosis Centre, Department of Paediatrics, Ghent University Hospital, Belgium
Cystic Fibrosis Centre, Department of Paediatrics, Ghent University Hospital, Belgium.
Nutr Clin Pract. 2015 Feb;30(1):134-7. doi: 10.1177/0884533614551838. Epub 2014 Oct 6.
The etiology of distal intestinal obstruction syndrome (DIOS) remains unclear. Food intake and pancreatic enzyme replacement therapy (PERT) are often blamed for its occurrence. This study evaluates the nutrition intake and PERT of patients with cystic fibrosis (CF) at a first episode of DIOS.
All patients with CF perform annually a 3-day intake diary to evaluate their caloric, protein, fat, dietary fiber, liquid, and PERT intake. Patients diagnosed with a first episode of DIOS (n = 12) retrospectively completed an intake diary of the 3 days preceding the DIOS episode supervised by an expert dietitian. RESULTS were compared with those of 1 year before and also with 36 CF controls matched for age, sex, genotype, and disease severity. All were pancreatic insufficient.
A first DIOS episode was diagnosed in 12 patients with CF. Only the absolute median fat intake (P = .015) and pancreatic enzyme intake (P = .035) were higher at the time of the DIOS attack in comparison to the preceding year. This could result from the difference in data collection or from the recommendations to increase fat intake and concomitant enzyme intake, since this trend was also found in the control group. The significant difference disappears when enzyme intake is expressed as units of lipase/g of fat. No other significant dietary differences were found.
This study provides no indications for a potential role of nutrition factors or pancreatic enzymes in the first occurrence of DIOS.
远端肠梗阻综合征（DIOS）的病因尚不清楚。食物摄入和胰酶替代疗法（PERT）常被认为是其发病原因。本研究评估了囊性纤维化（CF）患者首次发生DIOS时的营养摄入和PERT情况。
所有CF患者每年进行一次为期3天的摄入量记录，以评估其热量、蛋白质、脂肪、膳食纤维、液体和PERT摄入量。被诊断为首次发生DIOS的患者（n = 12）在专家营养师的监督下回顾性地完成了DIOS发作前3天的摄入量记录。将结果与前一年的结果进行比较，并与36名年龄、性别、基因型和疾病严重程度相匹配的CF对照者的结果进行比较。所有患者均为胰腺功能不全。
12例CF患者被诊断为首次发生DIOS。与前一年相比，仅在DIOS发作时绝对中位脂肪摄入量（P = .015）和胰酶摄入量（P = .035）较高。这可能是由于数据收集的差异或增加脂肪摄入和相应酶摄入的建议所致，因为在对照组中也发现了这种趋势。当酶摄入量以脂肪酶单位/克脂肪表示时，显著差异消失。未发现其他显著的饮食差异。
本研究未表明营养因素或胰酶在DIOS首次发生中具有潜在作用。
