Moccia M, Pappatà S, Erro R, Picillo M, Vitale C, Amboni M, Longo K, Palladino R, Barone P, Pellecchia Maria Teresa
Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.
Acta Neurol Scand. 2015 Feb;131(2):127-31. doi: 10.1111/ane.12295. Epub 2014 Oct 7.
Diagnosing Parkinson's disease (PD) and tracking its progression may require the combination of reliable biomarkers. Among them, both serum uric acid (UA) and dopamine transporter (DaT) binding deserve more investigations.
We aimed to investigate the relationship between serum UA levels and DaT availability in newly diagnosed, drug-naïve PD patients, by means of semiquantitative [(123) I]FP-CIT-SPECT.
We recruited 52 newly diagnosed, drug-naïve PD patients, and performed serum UA dosage and [(123) I]FP-CIT-SPECT.
Pearson's correlation analysis showed that UA levels were significantly higher in patients with higher averaged, ipsilateral and contralateral DaT binding in caudate, putamen, and striatum.
We showed, for the first time, by regional semiquantitative analysis of DaT binding in PD patients that UA levels significantly correlates with the severity of dopaminergic impairment in caudate, putamen, and striatum. This study broadens our knowledge on the importance of UA as a biomarker of PD.
诊断帕金森病（PD）及其病情进展可能需要多种可靠生物标志物的联合使用。其中，血清尿酸（UA）和多巴胺转运体（DaT）结合情况都值得进一步研究。
我们旨在通过半定量的[(123)I]FP-CIT单光子发射计算机断层扫描（SPECT），研究新诊断的、未接受过药物治疗的PD患者血清UA水平与DaT可用性之间的关系。
我们招募了52名新诊断的、未接受过药物治疗的PD患者，并进行了血清UA测定和[(123)I]FP-CIT SPECT检查。
Pearson相关性分析显示，在尾状核、壳核和纹状体中，平均、同侧和对侧DaT结合较高的患者，其UA水平显著更高。
我们首次通过对PD患者DaT结合进行区域半定量分析表明，UA水平与尾状核、壳核和纹状体中多巴胺能损伤的严重程度显著相关。本研究拓宽了我们对UA作为PD生物标志物重要性的认识。
