Department of Neurology Dokkyo Medical University Mibu Japan.
Department of Neurology Dokkyo Medical University Koshigaya Hospital Koshigaya Japan.
Brain Behav. 2016 Oct 31;7(1):e00598. doi: 10.1002/brb3.598. eCollection 2017 Jan.
Serum uric acid (UA) levels are reported to be decreased in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). However, clinical correlates of serum UA levels are still unclear in PD-related disorders. We conducted a cross-sectional study to evaluate the associations between serum UA levels and disease duration, disease severity, and motor function among PD, MSA, and progressive supranuclear palsy (PSP) patients.
A total of 100 patients with PD, 42 patients with MSA, 30 patients with PSP, and 100 controls were included in this study. Serum UA levels were determined, and associations among serum UA levels and disease duration, disease severity, and motor function in PD, PSP, and MSA patients were evaluated.
Serum UA levels were significantly lower in male PD, MSA, and PSP patients compared with the controls, but not in female patients. Serum UA levels were negatively correlated with disease duration and severity in MSA and PSP patients, but no correlations were observed in PD patients. The serum UA levels were significantly decreased in the tauopathy group (PSP patients) compared with the synucleinopathy group (PD and MSA patients) after adjusting for age, gender, and body mass index.
We found decreased serum UA levels in male patients with PD-related disorders (PD, MSA, and PSP) compared with male controls, and significant correlations between serum UA levels and disease severity in MSA and PSP patients.
据报道，帕金森病（PD）和多系统萎缩（MSA）患者的血清尿酸（UA）水平降低。然而，PD 相关疾病中血清 UA 水平与临床相关性仍不清楚。我们进行了一项横断面研究，以评估 PD、MSA 和进行性核上性麻痹（PSP）患者的血清 UA 水平与疾病持续时间、疾病严重程度和运动功能之间的关系。
本研究共纳入 100 例 PD 患者、42 例 MSA 患者、30 例 PSP 患者和 100 例对照者。测定血清 UA 水平，并评估 PD、PSP 和 MSA 患者血清 UA 水平与疾病持续时间、疾病严重程度和运动功能之间的关系。
与对照组相比，男性 PD、MSA 和 PSP 患者的血清 UA 水平显著降低，但女性患者则不然。血清 UA 水平与 MSA 和 PSP 患者的疾病持续时间和严重程度呈负相关，但在 PD 患者中未观察到相关性。在校正年龄、性别和体重指数后，tau 病组（PSP 患者）的血清 UA 水平明显低于 synucleinopathy 组（PD 和 MSA 患者）。
与男性对照组相比，我们发现 PD 相关疾病（PD、MSA 和 PSP）男性患者的血清 UA 水平降低，且 MSA 和 PSP 患者的血清 UA 水平与疾病严重程度之间存在显著相关性。
