Schneider E, Dy M
Inserm U 25 and Lab. Ass. CNRS 122, Hôpital Necker, 161 Rue de Sèvres, 75730 Paris Cedex 15, France.
Immunol Today. 1985 Apr;6(4):136-40. doi: 10.1016/0167-5699(85)90081-7.
Arginase activity - mainly known for its involvement in urea formation in the liver - inhibits DNA synthesis in cultured mammalian cells(1). Arginase is synthesised and released by activated macrophages mediating immunosuppression during mixed leucocyte culture(2) and may be implicated in macrophage cytotoxicity during the anti-tumor(3), anti-parasite(4) and anti-viral(5) responses. Here Elke Schneider and Michel Dy discuss these aspects of arginase activity as well as more recent indications that arginase may be involved in the cell differentiation and/or proliferation taking place during the immune responses(6,7). A lymphokine with arginase-enhancing activity has been identified. By producing ornithine, arginase provides the unique precursor of polyamines which are essential for DNA synthesis(8).
精氨酸酶活性——主要因其参与肝脏中尿素的形成而为人所知——可抑制培养的哺乳动物细胞中的DNA合成(1)。精氨酸酶由活化的巨噬细胞合成并释放，在混合淋巴细胞培养过程中介导免疫抑制(2)，并且在抗肿瘤(3)、抗寄生虫(4)和抗病毒(5)反应中可能与巨噬细胞的细胞毒性有关。在此，埃尔克·施耐德和米歇尔·迪讨论了精氨酸酶活性的这些方面，以及最近有关精氨酸酶可能参与免疫反应期间发生的细胞分化和/或增殖的迹象(6,7)。一种具有精氨酸酶增强活性的淋巴因子已被鉴定出来。通过产生鸟氨酸，精氨酸酶提供了多胺的独特前体，而多胺对于DNA合成至关重要(8)。
