Kundu M, Basu J, Rakshit M M, Chakrabarti P
Department of Chemistry, Bose Institute, India.
Biochim Biophys Acta. 1989 Oct 2;985(1):97-100. doi: 10.1016/0005-2736(89)90109-0.
The anion transport activities of erythrocytes from patients with chronic myelogenous leukemia (CML) and normal donors were comparable. In CML erythrocytes, significant reduction in the number of ankyrin-binding sites, present in the cytoplasmic domain of band 3, may lead to partial loss of cytoskeletal anchorage to the bilayer and account for their increased Con-A agglutinability and heat-sensitivity (Basu, J., Kundu, M., Rakshit, M.M. and Chakrabarti, P. (1988) Biochim. Biophys. Acta 945, 121-126).
慢性粒细胞白血病（CML）患者和正常供体的红细胞阴离子转运活性相当。在CML红细胞中，带3细胞质结构域中存在的锚蛋白结合位点数量显著减少，可能导致细胞骨架与双层膜的锚定部分丧失，并解释了它们凝集素-ConA凝集性增加和热敏感性增加的原因（Basu, J., Kundu, M., Rakshit, M.M.和Chakrabarti, P. (1988) Biochim. Biophys. Acta 945, 121 - 126）。
