Bottazzo G F, Bosi E, Bonifacio E, Mirakian R, Todd I, Pujol-Borrell R
Br Med Bull. 1989 Jan;45(1):37-57. doi: 10.1093/oxfordjournals.bmb.a072319.
By definition, autoimmunity is a circumvention of self-tolerance. Considering the complex network of control mechanisms which initiate and regulate immune responses to foreign agents and maintain the natural state of self-tolerance, autoimmunity may result from a weakening of this delicate equilibrium at various levels. Several hypotheses have therefore been put forward to explain the 'active' immunization process against self-constituents which are normally tolerated.
根据定义，自身免疫是对自身耐受性的规避。考虑到启动和调节针对外来病原体的免疫反应并维持自身耐受自然状态的复杂控制机制网络，自身免疫可能源于这一微妙平衡在各个层面的削弱。因此，人们提出了几种假说，以解释针对通常可耐受的自身成分的“主动”免疫过程。
