Cohen I R, Atlan H
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
J Autoimmun. 1989 Oct;2(5):613-25. doi: 10.1016/s0896-8411(89)80001-0.
Four classes of regulatory T lymphocytes have been implicated in the control of experimental autoimmune diseases: a pair of helper and suppressor T lymphocytes that recognize the self-antigen (antigen-specific); and a pair of helper and suppressor T lymphocytes that recognize the autoimmune effector lymphocytes (anti-idiotypic). The anti-idiotypic pair of regulators was detected following vaccination against autoimmune disease using autoimmune effector T clones as vaccines. To learn how the anti-idiotypic regulatory lymphocytes might function in concert with the antigen-specific regulatory lymphocytes, we devised a network in which the cell populations could be viewed as interconnected automata. Analysis of this novel network model suggests how self-tolerance may operate, how progressive autoimmune disease may develop, and how T-cell vaccination can control autoimmune disease.
四类调节性T淋巴细胞与实验性自身免疫性疾病的控制有关：一对识别自身抗原的辅助性和抑制性T淋巴细胞（抗原特异性）；以及一对识别自身免疫效应淋巴细胞的辅助性和抑制性T淋巴细胞（抗独特型）。在用自身免疫效应T克隆作为疫苗进行自身免疫性疾病疫苗接种后，检测到了抗独特型调节细胞对。为了了解抗独特型调节淋巴细胞如何与抗原特异性调节淋巴细胞协同发挥作用，我们设计了一个网络，其中细胞群体可被视为相互连接的自动机。对这个新型网络模型的分析表明了自身耐受性可能如何运作、进行性自身免疫性疾病可能如何发展以及T细胞疫苗接种如何控制自身免疫性疾病。
