Ratcliffe M J
Imperial Cancer Research Fund, Department of Zoology, University College, London WC 1E 6BT, UK.
Immunol Today. 1985 Jul;6(7):223-7. doi: 10.1016/0167-5699(85)90039-8.
A pluripotent or multipotent stem cell must undergo two major changes on the way to becoming an immunoglobulin (Ig) secreting B lymphocyte. Thefirst is the commitment to the lineage of a B cell rather than a T lymphocyte or other cell type. The second is a commitment to the production of antibody with a particular specificity. The latter involves selection of germ-line Ig variable region genes and the somatic rearrangements required for their expression (reviewed in detail elsewhere(1-4)). Since the selection of variable region genes for both Ig heavy and light chains (VH and VL) precedes the expression of Ig on the surface of the B cell(3), a sIgM(+) cell is committed both to the B-cell lineage and to the use of a particular combination of germ-line VH and VL genes. The chicken is one of the most convenient species with which to study lymphoid ontogeny. In this review Michael Ratcliffe examines recent evidence about the commitment of avian lymphoid cells as they progress from immature precursors to mature antibody producing cells.
多能或多潜能干细胞在成为分泌免疫球蛋白（Ig）的B淋巴细胞的过程中必须经历两个主要变化。第一个变化是确定成为B细胞谱系，而不是T淋巴细胞或其他细胞类型。第二个变化是确定产生具有特定特异性的抗体。后者涉及种系Ig可变区基因的选择及其表达所需的体细胞重排（在其他地方有详细综述(1-4)）。由于Ig重链和轻链（VH和VL）可变区基因的选择先于Ig在B细胞表面的表达(3)，一个表面IgM阳性（sIgM(+)）细胞既确定了B细胞谱系，也确定了使用特定组合的种系VH和VL基因。鸡是研究淋巴细胞个体发生最方便的物种之一。在这篇综述中，迈克尔·拉特克利夫研究了关于禽类淋巴细胞从未成熟前体发育为成熟抗体产生细胞过程中细胞定向分化的最新证据。
