Manley David W, Walton John C
University of St. Andrews , EaStCHEM School of Chemistry, St. Andrews, Fife, KY16 9ST, U.K.
Org Lett. 2014 Oct 17;16(20):5394-7. doi: 10.1021/ol502625w. Epub 2014 Oct 7.
A titania photoredox catalysis protocol was developed for the homocoupling of C-centered radicals derived from carboxylic acids. Intermolecular reactions were generally efficient and selective, furnishing the desired dimers in good yields under mild neutral conditions. Selective cross-coupling with two acids proved unsuccessful. An intramolecular adaptation enabled macrocycles to be prepared, albeit in modest yields.
开发了一种二氧化钛光氧化还原催化方案，用于羧酸衍生的碳中心自由基的均偶联反应。分子间反应通常高效且具有选择性，在温和的中性条件下能以良好的产率提供所需的二聚体。事实证明，两种酸的选择性交叉偶联反应并不成功。分子内反应可以制备大环化合物，不过产率一般。
