Wallentin Carl-Johan, Nguyen John D, Stephenson Corey R J
Department of Chemistry, Boston University, 590 Commonwealth Ave, Boston, MA 02215, USA.
Chimia (Aarau). 2012;66(6):394-8. doi: 10.2533/chimia.2012.394.
This mini-review highlights the Stephenson group's contribution to the field of photoredox catalysis with emphasis on carbon-carbon bond formation. The realization of photoredox mediated reductive dehalogenation initiated investigations toward both intra- and intermolecular coupling reactions. These reactions commenced via visible light-mediated reduction of activated halogens to give carbon-centered radicals that were subsequently involved in carbon-carbon bond forming transformations. The developed protocols using Ru and Ir based polypyridyl complexes as photoredox catalysts were further tuned to efficiently catalyze overall redox neutral atom transfer radical addition reactions. Most recently, a simplistic flow reactor technique has been utilized to affect a broad scope of photocatalytic transformations with significant enhancement in reaction efficiency.
本综述重点介绍了斯蒂芬森团队在光氧化还原催化领域的贡献，尤其侧重于碳-碳键的形成。光氧化还原介导的还原脱卤反应的实现引发了对分子内和分子间偶联反应的研究。这些反应通过可见光介导的活化卤素还原开始，生成碳中心自由基，随后这些自由基参与碳-碳键形成转化。使用钌和铱基多吡啶配合物作为光氧化还原催化剂开发的方案进一步优化，以有效催化整体氧化还原中性原子转移自由基加成反应。最近，一种简单的流动反应器技术已被用于实现广泛的光催化转化，反应效率有显著提高。
