Gatto P G, Bruzzoni A, Valenti V
Clin Ter. 1989 Jul 15;130(1):45-9.
A new long-acting theophylline formulation for once-daily administration has been tried in twenty patients with flare-ups of chronic obstructive bronchopulmonary disease (COPD). Clinical results were good and untoward side effects were not observed. Theophylline blood level was tested on the first day and once steady state had been achieved, and was always within the therapeutic range.