Gatto P G, Bruzzoni A, Valenti V
Clin Ter. 1989 Jul 15;130(1):45-9.
A new long-acting theophylline formulation for once-daily administration has been tried in twenty patients with flare-ups of chronic obstructive bronchopulmonary disease (COPD). Clinical results were good and untoward side effects were not observed. Theophylline blood level was tested on the first day and once steady state had been achieved, and was always within the therapeutic range.
一种用于每日一次给药的新型长效茶碱制剂已在20例慢性阻塞性支气管肺疾病（COPD）急性发作患者中进行了试验。临床结果良好，未观察到不良反应。在第一天以及达到稳态后检测了茶碱血药浓度，其始终在治疗范围内。
