Kusmartsev S A, Ogreba V I
Eksp Onkol. 1989;11(5):23-6.
The nonspecific suppressor activity of bone marrow cells (BMC) and spleen cells (SC) of C57B1/6 mice was studied at 7,12-dimethylbenz(a)anthracene-induced carcinogenesis. It is established that in the latent period of the tumour development and with its appearance the suppressor activity of BMC decreases, while SC-increases. The activity of the BMC suppressor factor which is determined by the inhibition of proliferation of mastocytoma P-815 cells in vitro did not change significantly.
在7,12-二甲基苯并(a)蒽诱导的致癌过程中，对C57B1/6小鼠的骨髓细胞（BMC）和脾细胞（SC）的非特异性抑制活性进行了研究。已确定在肿瘤发展的潜伏期及其出现时，BMC的抑制活性降低，而SC的抑制活性增加。通过体外抑制肥大细胞瘤P-815细胞增殖测定的BMC抑制因子的活性没有显著变化。
