Robins R A, Baldwin R W
Cancer Research Campaign Laboratories, University of Nottingham, Nottingham, NG7 2RD, UK.
Immunol Today. 1985 Feb;6(2):55-8. doi: 10.1016/0167-5699(85)90048-9.
The roles and relative importance of the various T-cell subsets in the rejection of tumours have long been the subject of controversy. In view of the fine specificity of in-vivo rejection responses with, for example, chemically induced tumours, a highly specific means of target cell killing suggests itself. These rejection responses appear to be T-cell mediated, with little evidence for the participation of antibody dependent mechanisms, so the obvious candidate for the role of tumour cell destroyer would be the cytotoxic T cell (CTL). However, with the advent of monoclonal antibodies which were thought to separate T cells alongfunctional lines into helper and suppressor/cytotoxic subsets, amore direct evaluation of the role of CTL in tumour rejection becamefeasible. In this article R. A. Robins and R. W. Baldwin discuss T-cell subsets in tumour rejection responses.
各种T细胞亚群在肿瘤排斥反应中的作用及相对重要性长期以来一直是争议的焦点。鉴于体内对化学诱导肿瘤等的排斥反应具有精细的特异性，一种高度特异性的靶细胞杀伤方式便应运而生。这些排斥反应似乎是由T细胞介导的，几乎没有证据表明抗体依赖性机制参与其中，因此，肿瘤细胞破坏者角色的明显候选者是细胞毒性T细胞（CTL）。然而，随着单克隆抗体的出现，人们认为可以根据功能将T细胞分为辅助性和抑制性/细胞毒性亚群，对CTL在肿瘤排斥反应中的作用进行更直接的评估变得可行。在本文中，R.A.罗宾斯和R.W.鲍德温讨论了肿瘤排斥反应中的T细胞亚群。
