Ulrik Charlotte Suppli
Lungemedicinsk Afdeling 253, Hvidovre Hospital, Kettegård Alle 30, 2650 Hvidovre.
Ugeskr Laeger. 2014 Jul 7;176(28):V01130052.
Long-acting bronchodilators are central for treatment of COPD. This short review provides an overview of studies evaluating the efficacy of aclidinium bromide, a long-acting anticholinergic bronchodilator, for the treatment of COPD. Twice-daily dosing of aclidinium leads to clinically important improvements in forced expiratory volume in 1 second, health status, use of rescue medication, day-time dyspnoea and exercise tolerance. The available studies also suggest an effect on night-time dyspnoea and exacerbation rate in patients with COPD. Aclidinium seems to have potential for a significant role in the future management of COPD.
长效支气管扩张剂是慢性阻塞性肺疾病（COPD）治疗的核心。本简短综述概述了评估长效抗胆碱能支气管扩张剂阿地溴铵治疗COPD疗效的研究。阿地溴铵每日两次给药可使1秒用力呼气容积、健康状况、急救药物使用、日间呼吸困难和运动耐力在临床上得到重要改善。现有研究还表明，其对COPD患者的夜间呼吸困难和急性加重率有影响。阿地溴铵似乎在COPD的未来管理中具有发挥重要作用的潜力。
