日本男性工人牙周病与心肌梗死关联的五年随访研究：MY健康提升研究

Five-year follow-up study of the association between periodontal disease and myocardial infarction among Japanese male workers: MY Health Up Study.

作者信息

Noguchi Satomi, Toyokawa Satoshi, Miyoshi Yuji, Suyama Yasuo, Inoue Kazuo, Kobayashi Yasuki

机构信息

Department of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Department of Health Policy and Technology Assessment, National Institute of Public Health, Saitama, Japan.

Department of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

出版信息

J Public Health (Oxf). 2015 Dec;37(4):605-11. doi: 10.1093/pubmed/fdu076. Epub 2014 Oct 7.

DOI:10.1093/pubmed/fdu076

PMID:25293424

Abstract

BACKGROUND

An association between chronic oral infections and coronary heart disease has been suggested.

METHODS

The study participants were male employees aged 36-59 years. Data were extracted from the MY Health Up Study, comprising a baseline questionnaire survey and succeeding annual health examinations for financial firm workers in Japan. Using a self-administered questionnaire at baseline, participants' oral status was classified into three types of periodontal indicators: (i) periodontal score, (ii) periodontitis and (iii) tooth loss (<5 and ≥5 teeth). An incidence of myocardial infarction (MI) was determined by annual health examination records.

RESULTS

Of the 4037 candidates for follow-up in the baseline year of 2004, 3081 males were eligible for the analysis, 17 of whom experienced MI in the subsequent 5 years. The periodontal score model was associated with an increase in developing MI [odds ratio (OR) = 2.11, 95% confidence interval (CI) = 1.29-3.44], after adjusting for other confounding variables. The periodontitis (OR = 2.26, 95% CI = 0.84-6.02) and tooth loss (OR = 1.97, 95% CI = 0.71-5.45) models showed similar trends, although the difference was not significant.

CONCLUSIONS

Periodontal disease may be a mild but independent risk factor for MI among Japanese male workers.

摘要

背景

慢性口腔感染与冠心病之间的关联已被提出。

方法

研究参与者为年龄在36 - 59岁的男性员工。数据取自“我的健康提升研究”，该研究包括对日本金融公司员工的基线问卷调查和随后的年度健康检查。在基线时使用自填式问卷，将参与者的口腔状况分为三种牙周指标类型：（i）牙周评分，（ii）牙周炎，（iii）牙齿缺失（<5颗和≥5颗牙齿）。心肌梗死（MI）的发病率通过年度健康检查记录确定。

结果

在2004年基线年的4037名随访候选人中，3081名男性符合分析条件，其中17人在随后5年中发生了心肌梗死。在调整其他混杂变量后，牙周评分模型与发生心肌梗死的增加相关[比值比（OR）= 2.11，95%置信区间（CI）= 1.29 - 3.44]。牙周炎（OR = 2.26，95% CI = 0.84 - 6.02）和牙齿缺失（OR = 1.97，95% CI = 0.71 - 5.45）模型显示出类似趋势，尽管差异不显著。