Rus Marius, Negruțiu Bianca Maria, Sava Cristian Nicolae, Pasca Georgeta, Andronie-Cioara Felicia Liana, Crisan Simina, Popescu Mircea-Ioachim, Staniș Claudia Elena, Judea Pusta Claudia
Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
Cardiology Department, Bihor Clinical Emergency Hospital, 410169 Oradea, Romania.
J Clin Med. 2025 Apr 3;14(7):2447. doi: 10.3390/jcm14072447.
This study investigated the association between periodontal disease and acute coronary syndrome (ACS), while examining periodontitis as an independent predictor of STEMI. This study included 166 patients with ACS, of whom 103 had a history of periodontal disease. The results showed that patients with periodontal disease were more likely to have a history of tobacco use (78.6%), diabetes (53.1%), and poor oral hygiene (72.8%). This study also found a significant association between periodontal disease and the severity of ACS (STEMI-44.7%, three-vessel/LM disease-30.1%), with patients experiencing more frequent and severe cardiovascular complications (HF-51.6%, valvulopathy and mechanical complications-22.6%, arrhythmias-19.4%). The findings support previous studies suggesting a link between periodontal disease and cardiovascular risk. This study highlights the importance of considering periodontal disease as a potential risk factor for cardiovascular disease and the need for improved access to oral health care to reduce the burden of cardiovascular events. Periodontal disease was identified as an independent predictor of STEMI, highlighting the need for periodontal health assessments as part of routine management in cardiovascular risk stratification. The precise mechanisms continue to be an area of active investigation.
本研究调查了牙周疾病与急性冠状动脉综合征（ACS）之间的关联，同时将牙周炎视为ST段抬高型心肌梗死（STEMI）的独立预测因素。本研究纳入了166例ACS患者，其中103例有牙周疾病史。结果显示，有牙周疾病的患者更有可能有吸烟史（78.6%）、糖尿病史（53.1%）和口腔卫生差（72.8%）。本研究还发现牙周疾病与ACS的严重程度之间存在显著关联（STEMI占44.7%，三支血管/左主干病变占30.1%），患者出现心血管并发症的频率更高、病情更严重（心力衰竭占51.6%，瓣膜病和机械并发症占22.6%，心律失常占19.4%）。这些发现支持了先前表明牙周疾病与心血管风险之间存在联系的研究。本研究强调了将牙周疾病视为心血管疾病潜在危险因素的重要性，以及改善口腔保健服务可及性以减轻心血管事件负担的必要性。牙周疾病被确定为STEMI的独立预测因素，这凸显了在心血管风险分层的常规管理中进行牙周健康评估的必要性。确切机制仍是一个积极研究的领域。
