Vrignaud Laura, Aouille Jerémie, Mallaret Michel, Durrieu Geneviève, Jonville-Béra Annie-Pierre
Centre régional de pharmacovigilance, de pharmacoépidémiologie et d'information sur le médicament, Service de pharmacologie clinique, CHRU de Tours, Tours, France.
Cabinet de psychiatrie, Tours, France.
Therapie. 2014 Nov-Dec;69(6):525-7. doi: 10.2515/therapie/2014064. Epub 2014 Oct 9.
We report the case of a patient with hypersexuality while he was treated with aripiprazole since 6 months. Clinical manifestations were an increased libido, unusual frequent masturbation and sexual instincts. All have resolved upon discontinuation of aripiprazole, and recurred after it was restarted. The partial dopaminergic agonist effect of aripiprazole could probably explain the occurrence of this compulsive behaviour.
我们报告了一例自6个月前开始使用阿立哌唑治疗的患者出现性欲亢进的病例。临床表现为性欲增强、异常频繁的手淫和性冲动。停用阿立哌唑后所有症状均消失，重新使用后症状复发。阿立哌唑的部分多巴胺能激动剂作用可能解释了这种强迫行为的发生。
