Nair Akshay Gopinathan, Nair Aditya Gopinathan, George Ronnie Jacob, Biswas Jyotirmay, Gandhi Rashmin Anilkumar
Sankara Nethralaya, Medical Research Foundation, Nungambakkam, Chennai, India.
Cutan Ocul Toxicol. 2012 Mar;31(1):74-6. doi: 10.3109/15569527.2011.603106. Epub 2011 Aug 10.
Aripiprazole is a drug belonging to the group of atypical antipsychotics. Ocular side effects of aripiprazole are rare. We report a case of transient myopia in a 33-year-old male who was being treated for schizophrenia with oral quetiapine and was recently supplemented with aripiprazole. One month after the addition of aripiprazole the patient reported sudden onset painless blurring of vision in both eyes. He was found to have myopia of-3.0 diopters in both eyes; his corrected visual acuity being 20/20. He was advised to discontinue aripiprazole. Ten days later on examination, the patient had an uncorrected visual acuity of 20/20 in both eyes. The stoppage of symptoms on stopping the drug indicates a strong correlation between the drug and the adverse effect. Ophthalmologists and psychiatrists must be aware of this reversible adverse drug reaction, so it may be treated promptly.
阿立哌唑是一种非典型抗精神病药物。阿立哌唑的眼部副作用罕见。我们报告一例33岁男性患者，该患者正在接受口服喹硫平治疗精神分裂症，近期加用了阿立哌唑，出现了短暂性近视。加用阿立哌唑一个月后，患者报告双眼突然出现无痛性视力模糊。检查发现他双眼近视-3.0屈光度；矫正视力为20/20。建议他停用阿立哌唑。十天后复查，患者双眼未矫正视力为20/20。停药后症状消失表明药物与不良反应之间有很强的相关性。眼科医生和精神科医生必须意识到这种可逆的药物不良反应，以便能及时进行治疗。
