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[达比加群治疗期间因急性肾衰竭导致的危及生命的出血]

[Life-threatening bleeding during dabigatran treatment because of acute renal failure].

作者信息

Madsen Henrik Bjørnsgaard, Lütken Sophie Constantin, Povlsen Jonas Agerlund, Løfgren Bø

机构信息

Medicinsk Afdeling, Regionshospitalet Randers, Skovlyvej 1, 8930 Randers. E-mail:

出版信息

Ugeskr Laeger. 2014;176(34).

Abstract

We report a case where a 64-year-old woman treated with dabigatran developed life-threatening bleeding due to lack of dose adjustment following identification of acute renal failure. Many commonly used drugs, e.g. new oral anticoagulants, digoxin, ACE-inhibitors, antibiotics, are eliminated by the kidneys. The case illustrates that lack of medication reconciliation can lead to serious adverse events in case of deteriorating organ function. The use of medication reconciliation should be performed on a daily basis and special attention should be exercised in case of reduced kidney function.

摘要

我们报告了一例64岁女性患者的病例,该患者在使用达比加群治疗期间,因急性肾衰竭确诊后未调整剂量而发生危及生命的出血。许多常用药物,如新口服抗凝剂、地高辛、血管紧张素转换酶抑制剂、抗生素等,均通过肾脏排泄。该病例表明,在器官功能恶化的情况下,缺乏用药核对可能导致严重不良事件。应每天进行用药核对,且在肾功能减退时应格外注意。

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