成年雌性大鼠长期服用舒必利后的摄食减少：D2多巴胺受体超敏模型？

Hypophagia after long-term administration of sulpiride in adult female rats: a model of D2 dopamine receptors supersensitivity?

作者信息

Baptista T

机构信息

Laboratorio de Fisiologia de la Conducta, Facultad de Medicina, Universidad de los Andes, Mérida, Venezuela.

出版信息

Med Hypotheses. 1989 Sep;30(1):5-8. doi: 10.1016/0306-9877(89)90117-5.

DOI:10.1016/0306-9877(89)90117-5

PMID:2529418

Abstract

Sulpiride (20 mg/kg/ip for 21 days) induced in female rats a significant body weight increase and hyperphagia. After drug withdrawal a significant hypophagia was observed. It is hypothesised that this hypophagia might be a spontaneous manifestation of D2 dopamine receptors supersensitivity, either in the perifornical region of the lateral hypothalamus or in the pituitary.

摘要

舒必利（20毫克/千克，腹腔注射，持续21天）可使雌性大鼠体重显著增加并出现食欲亢进。停药后观察到明显的食欲减退。据推测，这种食欲减退可能是下丘脑外侧穹窿周区或垂体中D2多巴胺受体超敏反应的自发表现。