Stamler J, Horowitz S F, Goldman M E, Matza D, Machac J
Mt Sinai J Med. 1989 Sep;56(4):285-9.
Peripartum cardiomyopathy is a syndrome of undetermined etiology whose most common initial symptoms are those of congestive heart failure. The syndrome carries a five-year mortality estimated at 40%. Single noxious factors, such as viral infection, have been proposed as direct precipitants of this syndrome, but none have been conclusively linked to it. The cases of two patients with identifiable cardiac stress factors who developed peripartum cardiomyopathy are presented here: one with sepsis complicated by disseminated intravascular coagulopathy and severe anemia, and a second with an otherwise normal pregnancy who engaged in strenuous aerobic exercise throughout the last trimester. A review of previously published cases reveals the frequent association of multiple nonspecific cardiac stress factors that may predispose women to peripartum cardiomyopathy. Various cardiac stress factors may act synergistically with the stress of pregnancy to precipitate peripartum cardiomyopathy in susceptible women.
围产期心肌病是一种病因不明的综合征，其最常见的初始症状是充血性心力衰竭的症状。该综合征的五年死亡率估计为40%。单一有害因素，如病毒感染，已被提出作为该综合征的直接促发因素，但尚无确凿证据表明其与之相关。本文介绍了两名患有可识别心脏应激因素并发展为围产期心肌病的患者病例：一名患有败血症并伴有弥散性血管内凝血和严重贫血，另一名在妊娠过程正常，但在妊娠最后三个月一直进行剧烈有氧运动。对先前发表病例的回顾显示，多种非特异性心脏应激因素经常同时出现，这些因素可能使女性易患围产期心肌病。各种心脏应激因素可能与妊娠应激协同作用，促使易感女性发生围产期心肌病。
