Luo Yue-qiu, Wu Xiao-xing, Ling Zong-xin, Cheng Yi-wen, Yuan Li, Xiang Charlie
State Key Laboratory for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou 310058, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China.
J Zhejiang Univ Sci B. 2014 Oct;15(10):900-6. doi: 10.1631/jzus.B1400073.
To conduct a systematic review of group studies assessing the association of serum vitamin D status with the severity of liver fibrosis in chronic hepatitis C patients using meta-analysis. The relevant research literatures were identified by searching PubMed and EMBASE databases prior to October 2013 with no restrictions. We included group studies that reported odds ratio (OR) estimates with 95% confidence intervals (CIs) or a mean with standard deviation (SD) for the association between serum vitamin D status and the severity of liver fibrosis in chronic hepatitis C patients. Approximately 8321 participants from several countries were included in this analysis. Six studies on serum vitamin D status and the severity of liver fibrosis were included in this meta-analysis. ORs with 95% CIs were extracted from four studies and the pooled ORs were 0.866 (95% CI, 0.649 to 1.157). The means with SDs were extracted from three studies and the pooled means were -0.487 (95% CI, -0.659 to -0.315). There was statistically significant heterogeneity among the mean data extracted studies (P=0.029; I(2)=71.8%) but not among the OR data extracted studies (P=0.061; I(2)=55.6%). Finally, results from the mean data extracted studies suggest that lower serum vitamin D is a risk factor for the severity of liver fibrosis in chronic hepatitis C patients. However, there is no conclusive evidence on this association because of inconsistencies between the OR data extracted studies and the mean data extracted studies.
采用荟萃分析方法对评估慢性丙型肝炎患者血清维生素D水平与肝纤维化严重程度之间关联的群组研究进行系统评价。通过检索截至2013年10月的PubMed和EMBASE数据库来确定相关研究文献，检索无限制条件。我们纳入了报告慢性丙型肝炎患者血清维生素D水平与肝纤维化严重程度之间关联的比值比（OR）估计值及95%置信区间（CI）或均值与标准差（SD）的群组研究。本分析纳入了来自几个国家的约8321名参与者。本荟萃分析纳入了六项关于血清维生素D水平与肝纤维化严重程度的研究。从四项研究中提取了95%CI的OR值，合并后的OR值为0.866（95%CI，0.649至1.157）。从三项研究中提取了均值与标准差，合并后的均值为-0.487（95%CI，-0.659至-0.315）。在提取均值数据的研究中存在统计学显著异质性（P=0.029；I²=71.8%），但在提取OR数据的研究中不存在（P=0.061；I²=55.6%）。最后，提取均值数据的研究结果表明，较低的血清维生素D水平是慢性丙型肝炎患者肝纤维化严重程度的一个危险因素。然而，由于提取OR数据的研究与提取均值数据的研究之间存在不一致性，关于这种关联尚无确凿证据。
