Ronichevskaia G M, Smirnov P N, Goncharova N B, Zlobina G A
Ontogenez. 1989 Jul-Aug;20(4):409-15.
Chalone-like proteoglycans from sheep and bovine thymus and spleen were shown to suppress cell proliferation in murine thymus or spleen. Their effect appeared to be organ-specific but not species-specific. Administration of the proteoglycans resulted in a decrease in the mitotic activity of thymus and spleen cells 24h (strain C57BL), three days (hybrids), four days (nude mice) or five days (highly cancerous strain C3H/He and white mongrel mice) after birth. These changes are probably due to genetic peculiarities of immune system formation in different mouse strains. The activity of chalone-like proteoglycans from spleen and thymus of 1-, 3- and 6-months old sheep was lower than that of adult sheep (two and five years old) indicating that the proteoglycan activity increases during ontogenesis.
来自绵羊和牛胸腺及脾脏的类抑素蛋白聚糖被证明可抑制小鼠胸腺或脾脏中的细胞增殖。它们的作用似乎具有器官特异性，但不具有物种特异性。在出生后24小时（C57BL品系）、三天（杂交种）、四天（裸鼠）或五天（高度癌化的C3H/He品系和白色杂种小鼠）给予蛋白聚糖后，胸腺和脾脏细胞的有丝分裂活性降低。这些变化可能归因于不同小鼠品系免疫系统形成的遗传特性。1个月、3个月和6个月大绵羊的脾脏和胸腺中的类抑素蛋白聚糖活性低于成年绵羊（2岁和5岁），这表明蛋白聚糖活性在个体发育过程中增加。
