Ronichevskaia G M, Rykova V I, Zvereva L N
Ontogenez. 1984 Sep-Oct;15(5):529-34.
A chalone-like proteoglycan was isolated from the liver of 2 and 24 month old cattle and Wistar rats which inhibited mitoses in the liver cells of C57BL mice starting from 5-6 days after birth. The effect of this proteoglycan was tissue but not species specific. We failed to isolate this proteoglycan from the liver of newborn rats, thus suggesting that either this substance is not produced by the cells of newborn animals or is produced in insignificant quantities. The proteoglycan isolated from the liver of the old rats, unlike that from the liver of 2 month old rats, was not effective in the same doses and this suggests changes in its chemical composition.
从2月龄和24月龄牛及Wistar大鼠的肝脏中分离出一种类抑素蛋白聚糖，该蛋白聚糖从出生后5 - 6天起就抑制C57BL小鼠肝细胞的有丝分裂。这种蛋白聚糖的作用具有组织特异性而非物种特异性。我们未能从新生大鼠的肝脏中分离出这种蛋白聚糖，这表明要么这种物质不是新生动物细胞产生的，要么产生的量极少。与从2月龄大鼠肝脏中分离出的蛋白聚糖不同，从老年大鼠肝脏中分离出的蛋白聚糖在相同剂量下无效，这表明其化学组成发生了变化。
