Grimm Verena, Westermann Christina, Riedel Christian U
Institute of Microbiology and Biotechnology, University of Ulm, 89068 Ulm, Germany.
Biomed Res Int. 2014;2014:960826. doi: 10.1155/2014/960826. Epub 2014 Sep 11.
Bifidobacteria are one of the predominant bacterial groups of the human intestinal microbiota and have important functional properties making them interesting for the food and dairy industries. Numerous in vitro and preclinical studies have shown beneficial effects of particular bifidobacterial strains or strain combinations on various health parameters of their hosts. This indicates the potential of bifidobacteria in alternative or supplementary therapeutic approaches in a number of diseased states. Based on these observations, bifidobacteria have attracted considerable interest by the food, dairy, and pharmaceutical industries and they are widely used as so-called probiotics. As a consequence of the rapidly increasing number of available bifidobacterial genome sequences and their analysis, there has been substantial progress in the identification of bifidobacterial structures involved in colonisation of and interaction with the host. With the present review, we aim to provide an update on the current knowledge on the mechanisms by which bifidobacteria colonise their hosts and exert health promoting effects.
双歧杆菌是人类肠道微生物群中主要的细菌群体之一，具有重要的功能特性，这使其在食品和乳制品行业备受关注。大量的体外和临床前研究表明，特定的双歧杆菌菌株或菌株组合对宿主的各种健康参数具有有益作用。这表明双歧杆菌在多种疾病状态的替代或补充治疗方法中具有潜力。基于这些观察结果，双歧杆菌引起了食品、乳制品和制药行业的极大兴趣，它们被广泛用作所谓的益生菌。由于可用双歧杆菌基因组序列数量的迅速增加及其分析，在鉴定参与宿主定植和相互作用的双歧杆菌结构方面取得了重大进展。通过本综述，我们旨在提供有关双歧杆菌定植宿主并发挥健康促进作用的机制的当前知识的最新情况。
