特发性颅内高压患者脑脊液分流术后的视野检查、视网膜神经纤维层厚度及视乳头水肿分级
Perimetry, retinal nerve fiber layer thickness and papilledema grade after cerebrospinal fluid shunting in patients with idiopathic intracranial hypertension.
作者信息
Rizzo Jennifer L, Lam Khoa V, Wall Michael, Wilson Machelle D, Keltner John L
机构信息
Department of Ophthalmology and Vision Science (JLR, KVL, JLK), University of California Davis Eye Center, Sacramento, California; Departments of Neurology and Ophthalmology and Visual Sciences (MW), University of Iowa, Iowa City, Iowa; Department of Public Health, Clinical and Translational Science Center (MDW), University of California Davis, Davis, California; and Departments of Neurology and Neurological Surgery (JLK), University of California Davis, Sacramento, California.
出版信息
J Neuroophthalmol. 2015 Mar;35(1):22-5. doi: 10.1097/WNO.0000000000000181.
BACKGROUND
To investigate the effect of cerebrospinal fluid (CSF) shunting on quantitative perimetry and papilledema in patients with uncontrolled idiopathic intracranial hypertension (IIH).
METHODS
We retrospectively reviewed all cases of IIH with CSF shunting at our institution between 2004 and 2011. Perimetry was performed before and after surgery in 15 patients, and the mean deviation (MD) was compared before and after surgery to assess the effect of the intervention.
RESULTS
Fourteen of the IIH patients were female and 1 was male. The average age was 34 years. CSF shunting resulted in significant improvement in the perimetric results with an increase in the MD of 5.63 ± 1.19 dB (P < 0.0001). Additionally, average retinal nerve fiber layer (RNFL) thickness measurement by optical coherence tomography decreased by 87.27 ± 16.65 μm (P < 0.0001), and Frisen papilledema grade decreased by 2.19 ± 0.71 (P < 0.0001).
CONCLUSIONS
Our results suggest that CSF shunting results in improvement in perimetry, RNFL swelling, and papilledema grade in patients with IIH.
背景
探讨脑脊液（CSF）分流术对特发性颅内高压（IIH）控制不佳患者定量视野检查和视乳头水肿的影响。
方法
我们回顾性分析了2004年至2011年间在我院接受CSF分流术的所有IIH病例。对15例患者在手术前后进行了视野检查，并比较手术前后的平均偏差（MD）以评估干预效果。
结果
14例IIH患者为女性，1例为男性。平均年龄为34岁。CSF分流术使视野检查结果有显著改善，MD增加了5.63±1.19 dB（P<0.0001）。此外，通过光学相干断层扫描测量的平均视网膜神经纤维层（RNFL）厚度减少了87.27±16.65μm（P<0.0001），弗里斯视乳头水肿分级降低了2.19±0.71（P<0.0001）。
结论
我们的结果表明，CSF分流术可改善IIH患者的视野检查、RNFL肿胀和视乳头水肿分级。
Zotero 插件