Calcara G, Rapisarda F, Rapisarda C, Brischetto R, Fatuzzo P, Seminara G, Vasta E, Motta M
Arch Ital Urol Nefrol Androl. 1989 Sep;61(3):229-33.
Hepatitis delta virus (HDV) is a defective virus which requires the helper function of hepatitis B virus (HBV) for replication. HDV infection occurs only during or after HDV infection. Viral infection spreads parenterally in both cases. However, it has been reported that the risk of HDV infection is limited to hemodialysed patients, unlike the risk of HBV infection. In order to verify these findings the Authors studied 108 patients undergoing periodical hemodialytic treatment in order to study the delta antibodies present in their blood. Sixty-one of these subjects had received previous blood transfusions, 15 were HBsAg positive and 7 positive for other serological markers of the hepatitis B virus. None of the subjects examined was positive for anti HDV. Our results agreed with the literature reporting an incidence of positive HDV serological markers limited to hemodialyzed patients. The Authors observed that the behaviour of the HDV serological markers can vary from patient to patient and that it is impossible to furnish diagnosis of HDV infection after HBV and HDV clearance. Since these factors can lead to underestimation of the real incidence of HDV infection in hemodialyzed patients, the Authors underline the need to perform long term epidemiological studies and to investigate all the HDV serological markers.
丁型肝炎病毒（HDV）是一种缺陷病毒，其复制需要乙型肝炎病毒（HBV）的辅助功能。HDV感染仅在HBV感染期间或之后发生。在这两种情况下，病毒感染均通过非肠道途径传播。然而，据报道，与HBV感染风险不同，HDV感染风险仅限于接受血液透析的患者。为了验证这些发现，作者对108例接受定期血液透析治疗的患者进行了研究，以检测他们血液中存在的丁型抗体。这些受试者中有61人曾接受过输血，15人HBsAg呈阳性，7人乙型肝炎病毒的其他血清学标志物呈阳性。所有接受检查的受试者抗HDV均为阴性。我们的结果与文献报道一致，即HDV血清学标志物阳性的发生率仅限于接受血液透析的患者。作者观察到，HDV血清学标志物的表现因患者而异，并且在HBV和HDV清除后无法做出HDV感染的诊断。由于这些因素可能导致低估接受血液透析患者中HDV感染的实际发生率，作者强调需要进行长期的流行病学研究并检测所有HDV血清学标志物。
