Ma C, Zhou Q L, Deng Y J, Liang X, Wu D P, Dong Y Z
Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, China.
Department of Anesthesiology, The First Affiliated Hospital of Xinxiang Medical College, Xinxiang, China.
Genet Mol Res. 2014 Sep 26;13(3):7791-9. doi: 10.4238/2014.September.26.17.
The vitamin D receptor BsmI gene polymorphism is reportedly associated with low bone mineral density (BMD) in postmenopausal women, but results from previous studies are conflicting. In the present study, we investigated the association between this polymorphism and the risk of low BMD through a meta-analysis of published studies. A literature search of the Pubmed, Embase, and CNKI databases from inception through July 2013 was conducted. The meta-analysis was performed using the STATA 12.0 software. Crude odds ratios with 95% confidence intervals were used to assess the strength of any association. Eleven case-control studies were included for a total of 1468 low BMD cases and 2177 healthy controls. No significant variation in low BMD risk was detected in any of the genetic models. Further stratified analyses were performed to examine the effect of ethnicity. In the subgroup analysis, no significant association was found in Caucasians and in Asians. The meta-analysis results suggest that the BsmI polymorphism is not associated with low BMD risk in postmenopausal women.
据报道，维生素D受体BsmI基因多态性与绝经后女性的低骨密度（BMD）有关，但先前研究的结果相互矛盾。在本研究中，我们通过对已发表研究的荟萃分析，调查了这种多态性与低骨密度风险之间的关联。对PubMed、Embase和CNKI数据库从创建至2013年7月进行了文献检索。使用STATA 12.0软件进行荟萃分析。采用95%置信区间的粗比值比来评估任何关联的强度。纳入了11项病例对照研究，共有1468例低骨密度病例和2177例健康对照。在任何遗传模型中均未检测到低骨密度风险的显著差异。进行了进一步的分层分析以检查种族的影响。在亚组分析中，在白种人和亚洲人中均未发现显著关联。荟萃分析结果表明，BsmI多态性与绝经后女性的低骨密度风险无关。
