饮酒与巴雷特食管的肿瘤进展：一项系统评价和荟萃分析。
Alcohol consumption and the neoplastic progression in Barrett's esophagus: a systematic review and meta-analysis.
作者信息
Lou Zhifeng, Xing Haibo, Li Da
机构信息
The department of stomatology, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China.
The department of intensive care unit, Xiasha Hospital, Hangzhou, Zhejiang, P. R. China.
出版信息
PLoS One. 2014 Oct 9;9(10):e105612. doi: 10.1371/journal.pone.0105612. eCollection 2014.
PURPOSE
In the developed countries, the incidence of esophageal adenocarcinoma (EAC) is increasing over recent decades. The purpose of this meta-analysis was to arrive at quantitative conclusions about the contribution of alcohol intakes and the progression of Barrett's esophagus.
METHODS
A comprehensive, systematic bibliographic search of medical literature published up to Oct 2013 was conducted to identify relevant studies. A meta-analysis was conducted for alcohol consumption on the Barrett's esophagus progression.
RESULTS
A total of 882 cases in 6,867 individuals from 14 observational studies were indemnified in this meta-analysis. The result of this current meta-analysis, including 10 case-control and 4 cohort studies, indicated that alcohol consumption was not associated with the neoplastic progression in Barrett's esophagus (RR, 1.17; 95% CI, 0.93-1.48). When stratified by the study designs, no significant association was detected in either high vs low group or ever vs never group.
CONCLUSIONS
Alcohol drinking is not associated with risk of neoplastic progression in Barrett's esophagus. Further well designed studies are needed in this area.
目的
在发达国家，近几十年来食管腺癌（EAC）的发病率呈上升趋势。本荟萃分析的目的是就酒精摄入量与巴雷特食管进展之间的关系得出定量结论。
方法
对截至2013年10月发表的医学文献进行全面、系统的文献检索，以确定相关研究。对酒精消费与巴雷特食管进展进行荟萃分析。
结果
本荟萃分析纳入了14项观察性研究中的6867名个体的882例病例。本次荟萃分析的结果，包括10项病例对照研究和4项队列研究，表明饮酒与巴雷特食管的肿瘤进展无关（风险比，1.17；95%置信区间，0.93 - 1.48）。按研究设计分层时，在高暴露组与低暴露组或曾经饮酒组与从不饮酒组中均未检测到显著关联。
结论
饮酒与巴雷特食管的肿瘤进展风险无关。该领域需要进一步设计良好的研究。
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