Jiang Guoping, Yu Ke, Shao Lifang, Yu Xiaobo, Hu Chen, Qian Pei, Xie Haiyang, Li Jinjun, Zheng Jie, Zheng Shusen
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Rd, Hangzhou, 310003, China.
Key Laboratory of Combined Multi-organ Transplantation of Ministry of Public Health, Hangzhou, China.
BMC Cancer. 2015 Apr 25;15:314. doi: 10.1186/s12885-015-1318-6.
The association between epidermal growth factor (EGF) gene +61A/G polymorphism (rs4444903) and hepatocellular carcinoma (HCC) susceptibility has been widely reported, but the results were inconsistent. To clarify the effect of this polymorphism on HCC risk, a meta-analysis was performed.
The PubMed, Embase, Cochrane Library, Web of Science, Chinese BioMedical Literature (CBM), Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant studies published up to December 2013. Data were extracted independently by two authors. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to assess the strength of association.
A total of 16 studies including 2475 HCC cases and 5381 controls were included in this meta-analysis. Overall, a significantly increased HCC risk was observed under all genetic models (G vs. A: OR = 1.383, P < 0.001, 95% CI: 1.174-1.629; GG vs. GA + AA: OR = 1.484, P < 0.001, 95% CI: 1.198-1.838; GG + GA vs. AA: OR = 1.530, P < 0.001, 95% CI: 1.217-1.924; GG vs. AA: OR = 1.958, P < 0.001, 95% CI: 1.433-2.675; GA vs. AA: OR = 1.215, P = 0.013, 95% CI: 1.041-1.418). In the subgroup analyses by ethnicity, a significant association with HCC risk was found in Asian populations (G vs. A: OR = 1.151, P = 0.001, 95% CI: 1.056-1.255), European populations (G vs. A: OR = 1.594, P = 0.027, 95% CI: 1.053-2.413, and African populations (G vs. A: OR = 3.599, P < 0.001, 95% CI: 2.550-5.080), respectively.
Our study shows that EGF +61A/G polymorphism is significantly associated with the increased HCC risk, especially in Asian populations. Further large-scale and well-designed studies are required to confirm this conclusion.
表皮生长因子（EGF）基因+61A/G多态性（rs4444903）与肝细胞癌（HCC）易感性之间的关联已被广泛报道，但结果并不一致。为了阐明这种多态性对HCC风险的影响，我们进行了一项荟萃分析。
系统检索了PubMed、Embase、Cochrane图书馆、Web of Science、中国生物医学文献数据库（CBM）、万方数据库和中国知网（CNKI），以识别截至2013年12月发表的相关研究。由两位作者独立提取数据。计算比值比（OR）和95%置信区间（95%CI）以评估关联强度。
本荟萃分析共纳入16项研究，包括2475例HCC病例和5381例对照。总体而言，在所有遗传模型下均观察到HCC风险显著增加（G vs. A：OR = 1.383，P < 0.001，95%CI：1.174 - 1.629；GG vs. GA + AA：OR = 1.484，P < 0.001，95%CI：1.198 - 1.838；GG + GA vs. AA：OR = 1.530，P < 0.001，95%CI：1.217 - 1.924；GG vs. AA：OR = 1.958，P < 0.001，95%CI：1.433 - 2.675；GA vs. AA：OR = 1.215，P = 0.013，95%CI：1.041 - 1.418）。在按种族进行的亚组分析中，亚洲人群（G vs. A：OR = 1.151，P = 0.001，95%CI：1.056 - 1.255）、欧洲人群（G vs. A：OR = 1.594，P = 0.027，95%CI：1.053 - 2.413）和非洲人群（G vs. A：OR = 3.599，P < 0.001，95%CI：2.550 - 5.080）中均发现与HCC风险存在显著关联。
我们的研究表明，EGF +61A/G多态性与HCC风险增加显著相关，尤其是在亚洲人群中。需要进一步开展大规模、设计良好的研究来证实这一结论。
