缺血性心脏病患者在肱动脉血流介导的血管扩张过程中C反应蛋白水平升高及高频血管运动增强。

Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation.

作者信息

Watanabe Shogo, Amiya Eisuke, Watanabe Masafumi, Takata Munenori, Ozeki Atsuko, Watanabe Aya, Kawarasaki Shuichi, Nakao Tomoko, Hosoya Yumiko, Nagata Kohzo, Nagai Ryozo, Komuro Issei

机构信息

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Aichi, Japan.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

出版信息

PLoS One. 2014 Oct 9;9(10):e110013. doi: 10.1371/journal.pone.0110013. eCollection 2014.

DOI:10.1371/journal.pone.0110013

PMID:25299643

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4192359/

Abstract

PURPOSE

The physiological role of vasomotion, rhythmic oscillations in vascular tone or diameter, and its underlying mechanisms are unknown. We investigated the characteristics of brachial artery vasomotion in patients with ischemic heart disease (IHD).

METHODS

We performed a retrospective study of 37 patients with IHD. Endothelial function was assessed using flow-mediated dilation (FMD), and power spectral analysis of brachial artery diameter oscillations during FMD was performed. Frequency-domain components were calculated by integrating the power spectrums in three frequency bands (in ms2) using the MemCalc (GMS, Tokyo, Japan): very-low frequency (VLF), 0.003-0.04 Hz; low frequency (LF), 0.04-0.15 Hz; and high frequency (HF), 0.15-0.4 Hz. Total spectral power (TP) was calculated as the sum of all frequency bands, and each spectral component was normalized against TP.

RESULTS

Data revealed that HF/TP closely correlated with FMD (r = -0.33, p = 0.04), whereas VLF/TP and LF/TP did not. We also explored the relationship between elevated C-reactive protein (CRP) levels and vasomotion. HF/TP was significantly increased in subjects with high CRP levels (CRP;>0.08 mg/dL) compared with subjects with low CRP levels (0.052±0.026 versus 0.035±0.022, p<0.05). The HF/TP value closely correlated with CRP (r = 0.24, p = 0.04), whereas the value of FMD did not (r = 0.023, p = 0.84). In addition, elevated CRP levels significantly increased the value of HF/TP after adjustment for FMD and blood pressure (β = 0.33, p<0.05).

CONCLUSION

The HF component of brachial artery diameter oscillation during FMD measurement correlated well with FMD and increased in the presence of elevated CRP levels in subjects with IHD.

摘要

目的

血管运动（血管张力或直径的节律性振荡）的生理作用及其潜在机制尚不清楚。我们研究了缺血性心脏病（IHD）患者肱动脉血管运动的特征。

方法

我们对37例IHD患者进行了一项回顾性研究。使用血流介导的血管舒张（FMD）评估内皮功能，并对FMD期间肱动脉直径振荡进行功率谱分析。使用MemCalc（日本东京GMS公司）通过对三个频带（单位为ms2）的功率谱进行积分来计算频域分量：极低频（VLF），0.003 - 0.04Hz；低频（LF），0.04 - 0.15Hz；高频（HF），0.15 - 0.4Hz。总谱功率（TP）计算为所有频带之和，每个谱分量相对于TP进行归一化。

结果

数据显示，HF/TP与FMD密切相关（r = -0.33，p = 0.04），而VLF/TP和LF/TP则不然。我们还探讨了C反应蛋白（CRP）水平升高与血管运动之间的关系。与CRP水平低的受试者相比，CRP水平高（CRP>0.08mg/dL）的受试者HF/TP显著升高（0.052±0.026对0.035±0.022，p<0.05）。HF/TP值与CRP密切相关（r = 0.24，p = 0.04），而FMD值则不然（r = 0.023，p = 0.84）。此外，在调整FMD和血压后，CRP水平升高显著增加了HF/TP值（β = 0.33，p<0.05）。