在存在缺血性心脏病的情况下，血流介导的血管舒张过程中动脉搏动的增强会受到损害。

Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease.

作者信息

Amiya Eisuke, Watanabe Masafumi, Watanabe Shogo, Takata Munenori, Komuro Issei

机构信息

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655 Japan.

Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi Japan.

出版信息

Springerplus. 2016 Jul 16;5(1):1103. doi: 10.1186/s40064-016-2794-0. eCollection 2016.

DOI:10.1186/s40064-016-2794-0

PMID:27468404

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4947464/

Abstract

PURPOSE

The aim of this study is to investigate the relationship between arterial pulse amplitude change under increased shear stress and the presence of ischemic heart disease (IHD).

METHODS

This study comprised 31 subjects, including 14 subjects with IHD. We investigated the change in brachial artery pulse amplitude during flow-mediated dilation (FMD) using ultrasonography.

RESULTS

The arterial pulse amplitude increased during FMD in 19 subjects, whereas it decreased in 12 subjects. There was a marked difference in the change in arterial pulse amplitude (the maximum amplitude of the arterial pulse amplitude during FMD/the arterial pulse amplitude at baseline) between subjects with and without IHD (0.98 ± 0.53 and 1.37 ± 0.53, p = 0.028). Furthermore, decreased arterial pulse amplitude during FMD was a significant predictor of IHD after adjustment of age, blood pressure, the presence of each type of coronary risks, the value of FMD and sex (p = 0.0001).

CONCLUSIONS

The decrease of arterial pulsation amplitude during FMD was a useful predictive parameter for IHD.

摘要

目的

本研究旨在探讨剪切应力增加时动脉脉搏振幅变化与缺血性心脏病（IHD）之间的关系。

方法

本研究纳入31名受试者，其中14名患有IHD。我们使用超声检查研究了血流介导的血管舒张（FMD）过程中肱动脉脉搏振幅的变化。

结果

19名受试者在FMD期间动脉脉搏振幅增加，而12名受试者动脉脉搏振幅降低。患有和未患有IHD的受试者之间，动脉脉搏振幅变化（FMD期间动脉脉搏振幅的最大幅度/基线时的动脉脉搏振幅）存在显著差异（分别为0.98±0.53和1.37±0.53，p=0.028）。此外，在调整年龄、血压、各类冠心病风险因素、FMD值和性别后，FMD期间动脉脉搏振幅降低是IHD的显著预测指标（p=0.0001）。